The aim of the study was to assess whether children’s age at their parents’ divorce is associated with their chance of suffering from depression in early and mid-adulthood, as indicated by medication use. Unlike the few previous investigations, based on rather small datasets, a sibling comparison method was used. The data were extracted from the Norwegian Population Register and the Norwegian Prescription Database and included nearly 200,000 individuals aged 20-44 who had experienced parental divorce. Controlling for age in 2004, sex and birth order, children’s age at parental divorce was inversely related to their chance of purchasing antidepressants in 2004-08. For example, children who were aged 15-19 when their parents divorced were 16 percent less likely to purchase antidepressants than those experiencing the divorce at age 0-4. This is partly due to differences in educational achievements. The association was particularly strong for women and those whose mother had low education.