The objective of this study is to decompose the sex-mortality differential by age groups and cause of death in twelve American countries, between the years 2000 and 2014, using Pollard method. Preliminary results show that the age pattern of the sex-mortality differential is very similar across countries, with the more advanced ages have a greater impact. In addition, the young adult ages also has a significant participation on the sex-mortality differential, especially in countries with high mortality rates by violent causes and accidents. Cardiovascular diseases are the causes that most explain the mortality gap between females and males in Argentina, Canada, Chile, the United States of America and Uruguay while the accidents and violent causes are the causes that most explain the mortality gap between females and males in Brazil, Colombia, Costa Rica, Ecuador, Mexico, Paraguay and Peru.